SHP1‐ing thymic selection
نویسندگان
چکیده
منابع مشابه
Thymic selection and autoimmunity
APC = antigen presenting cell; cTEC = thymic cortical epithelial cell; DC = dendritic cell; IκB = inhibitory κB; IL = interleukin; mTEC = medullary thymic epithelial cell; NFκB = nuclear factor κB; NIK = NFκB inhibitory kinase; NOD = non-obese diabetic; NZB = New Zealand black; TLR = tolllike receptor; TNF = tumor necrosis factor; TRAF6 = TNF receptor associated factor 6. Arthritis Research & T...
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Cell division during thymic selection was studied with a system in which purified populations of T cell antigen receptor (TCR)- CD4+8+ (double-positive [DP]) cells and fetal thymic epithelial cells (TEC) were reaggregated in tissue culture. In this system, immature DP cells differentiate into mature single-positive (SP) CD4+8- and CD4-8+ TCRhi cells within 3-4 d, indicative of positive selectio...
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TOLERANCE (which is antigen-specific) must be distinguished from immune deficiency (non-specific). Its most important manifestation, the maintenance of SELFTOLERANCE, was originally explained by the Clonal Selection theory as the result of CLONAL ABORTION of self-reactive clones. However, potentially self-reactive Tand B-cells do exist in normal individuals, leading to the recognition of the im...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2016
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.201646582